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The charges announced by Attorney General Merrit Garland on Thursday include civil rights violations, conspiracy, use of excessive force offenses and obstruction.
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Police shot and killed the 22-year-old Black man while executing a no-knock search warrant last week. Protesters called for the resignation of the chief and the officer they say shot Locke.
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The death of Breonna Taylor energized a nationwide movement to restrict "no-knock" police raids, but activists want tightened rules for other kinds of forced-entry search warrants.